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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Cresol is produced by Clostridia bacteria, particularly C. difficile, and interferes with dopamine beta-hydroxylase, the enzyme converting dopamine to norepinephrine.
