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Excellent 4.6 out of 5
Functional / Endotoxin Activity

Hexa-LPS Index Gut Microbiome Test

Take the Hexa-LPS Index Test to better understand your gut inflammation risk and receive clear, practical guidance to support your digestive health.

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Key Insights

  • See how the balance of inflammatory vs. noninflammatory lipopolysaccharides in your gut points to your baseline endotoxin signaling and barrier stress.
  • Identify a higher share of hexa-acylated LPS signatures that may help explain bloating, food-reactivity, brain fog, skin flares, or post-meal fatigue.
  • Clarify how diet pattern, recent antibiotics, stress, or infections may be shifting your microbiome toward more or less TLR4-activating LPS.
  • Support personalized nutrition and lifestyle strategies with your clinician by understanding your gut’s LPS profile and related inflammatory tone.
  • Track changes in your hexa-LPS index over time to see how interventions influence microbial balance, gut barrier stability, and systemic reactivity.
  • If appropriate, integrate results with inflammation and metabolic panels such as hs-CRP, LBP, sCD14, glucose, or lipids for a fuller view of health status.

What is a Gut Microbiome Test?

The hexa-LPS index test is a focused microbiome assessment that analyzes genetic material from stool to profile the microbial community and estimate the relative potential to produce hexa-acylated lipopolysaccharides, the lipid A forms known to robustly activate the TLR4 receptor. Modern sequencing such as 16S rRNA or shotgun metagenomics identifies which organisms and pathways are present, then bioinformatic models summarize the balance of proinflammatory hexa-acylated LPS compared with hypo-acylated variants. Some laboratories complement this with host-response markers that reflect exposure to gut-derived endotoxin. Results capture your current ecosystem state rather than a permanent trait, and they can vary with recent diet, medications, illness, or travel.

Why Is It Important to Test Your Gut Microbiome?

Your gut microbes make molecules that talk to your immune system all day long. Lipopolysaccharides are one of the loudest voices in that conversation. When the community tilts toward hexa-acylated LPS producers, even routine events like a high-fat restaurant meal can generate a transient bump in circulating endotoxin signals. For some people, that looks like a heavy, sleepy feeling after lunch, skin redness later in the day, or a next-morning dip in workout pop. Testing helps identify dysbiosis patterns that elevate TLR4 signaling and may be linked with digestive discomfort, metabolic strain, or immune reactivity. It can also clarify the after-effects of antibiotics, restrictive dieting, or chronic stress on your gut’s inflammatory set point. The test is especially informative when symptoms persist despite basic nutrition and sleep hygiene, or after big lifestyle changes when you want to see how your microbiome adapted.

What Insights Will I Get From a Gut Microbiome Test?

Your report typically presents an index or proportion that reflects the predicted share of hexa-acylated LPS capacity within your microbial community, compared with a reference population. Many summaries also highlight the organisms and pathways that pull the index up or down. In general, a balanced microbiome shows higher diversity with a healthy presence of organisms associated with short-chain fatty acid production and a comparatively lower hexa-LPS signal. Conversely, a community enriched in certain Enterobacteriaceae tends to raise the index. Remember that “normal” varies by geography, age, and diet. Two people can eat very differently and still land in a resilient range if their ecosystems are stable and diverse.

When results lean toward balanced or optimal, it suggests efficient fermentation of fibers into short-chain fatty acids that nourish the gut lining, lower inflammatory signaling, and reinforce tight junctions. That physiology often pairs with steadier energy after meals and fewer swings in appetite or mood. When results suggest an imbalanced or dysbiotic state, you might see reduced diversity, a relative loss of beneficial genera, and a higher hexa-LPS index that points to stronger TLR4 activation. That is not a diagnosis. It is a map of functional tendencies that may underlie symptoms such as bloating, irregularity, or skin reactivity, and that may respond as your diet quality, stress load, sleep regularity, and medication landscape change.

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Frequently Asked Questions About Hexa-LPS Index Test

What does the hexa-lps index test measure?

The Hexa-LPS Index Test analyzes the genetic material of bacteria, fungi, and other microorganisms in stool to identify species diversity, relative abundance, and the functional potential of the microbiome.

Results provide an assessment of microbial balance and potential metabolic functions—what organisms are present and in what proportions—but they indicate microbial composition and balance, not the presence or diagnosis of specific diseases.

How is a hexa-lps index sample collected?

The hexa-lps index test is a simple at‑home stool collection using the small swab or vial provided in the kit: you collect a small amount of stool as directed, place it into the supplied tube or swab container, and seal it for return to the lab.

Maintain cleanliness to avoid contamination (wash hands before and after, avoid touching the collection tip), clearly label the sample with the required information (name, date/time), and follow the kit instructions and shipping guidelines exactly—these steps are essential to ensure accurate sequencing results.

What can my hexa-lps index test results tell me about my health?

Your Hexa‑LPS Index Test results can provide actionable insights into several aspects of gut and overall health: patterns associated with digestion (how well your microbiome is breaking down food), signs of intestinal and systemic inflammation, potential impacts on nutrient absorption, shifts in metabolic processes tied to microbial activity, and signals that relate to gut–brain communication (which can influence mood, sleep, and cognitive function).

These microbiome patterns can correlate with certain symptoms or risks but do not by themselves diagnose specific diseases; results should be interpreted as one piece of your health picture alongside clinical evaluation, laboratory tests, and medical history—discuss findings with your healthcare provider to determine appropriate next steps.

How accurate or reliable are hexa-lps index tests?

Next‑generation sequencing provides high-resolution microbial data that can detect and quantify many bacterial signatures underlying the Hexa‑LPS Index, but interpretation of Hexa‑LPS Index Test results is probabilistic rather than definitive—the index estimates likelihoods or relative shifts in LPS‑related microbial patterns, not absolute diagnoses. Technical accuracy depends on sample quality, laboratory processing and bioinformatic pipelines, so sequencing is powerful for detecting DNA signals but clinical interpretation requires caution.

Results reflect a snapshot in time and can change with recent diet, stress, illness or antibiotic use, so a single test may not represent long‑term status; correlation with symptoms, clinical history and, when appropriate, repeat or complementary testing improves reliability.

How often should I test my hexa-lps index?

Many people test their hexa-lps index once per year to establish a baseline, or more frequently—every 3–6 months—if they are actively adjusting diet, taking probiotics, starting medications, or making other interventions that could affect gut-derived LPS levels.

More important than a single reading is tracking the hexa-lps index over time: compare sequential results to see trends and the effect of interventions, which gives far more useful information than one-off measurements.

Can hexa-lps index populations change quickly?

Yes — microbial populations, including those that contribute to a hexa‑LPS index, can shift quite rapidly: short‑term perturbations such as changes in diet, antibiotics, illness, travel or stress can alter relative abundances within days. However, more stable community patterns and typical index values usually emerge only over weeks to months as transient fluctuations settle.

For meaningful comparisons, keep lifestyle and diet consistent before retesting: avoid introducing new medications, major dietary shifts, or significant travel immediately prior to sampling, and allow several weeks to months for the microbiome to stabilize so results reflect durable change rather than short‑lived variation.

Are hexa-lps index test results diagnostic?

No — hexa‑LPS index results highlight patterns of imbalance or resilience in the measured signals and are not standalone medical diagnoses.

These results must be interpreted alongside symptoms, medical history, and other laboratory or biomarker data by a qualified clinician for any diagnostic conclusions or treatment decisions.

How can I improve my hexa-lps index after testing?

Hexa-lps index test results can guide evidence‑based adjustments to improve your score by tailoring diet and lifestyle: modify fiber intake to increase diversity and soluble fiber, introduce targeted prebiotics to feed beneficial microbes, consider specific probiotic strains when appropriate, optimize hydration to support gut transit, and use stress‑management techniques to reduce gut permeability and inflammation.

Because individual responses vary, these changes are best planned and monitored with a healthcare professional who can interpret your hexa‑lps results, incorporate your medical history, recommend appropriate products/doses, and arrange follow‑up testing to track progress.

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