Key Insights
- See how the balance of inflammatory vs. noninflammatory lipopolysaccharides in your gut points to your baseline endotoxin signaling and barrier stress.
- Identify a higher share of hexa-acylated LPS signatures that may help explain bloating, food-reactivity, brain fog, skin flares, or post-meal fatigue.
- Clarify how diet pattern, recent antibiotics, stress, or infections may be shifting your microbiome toward more or less TLR4-activating LPS.
- Support personalized nutrition and lifestyle strategies with your clinician by understanding your gut’s LPS profile and related inflammatory tone.
- Track changes in your hexa-LPS index over time to see how interventions influence microbial balance, gut barrier stability, and systemic reactivity.
- If appropriate, integrate results with inflammation and metabolic panels such as hs-CRP, LBP, sCD14, glucose, or lipids for a fuller view of health status.
What is a Gut Microbiome Test?
The hexa-LPS index test is a focused microbiome assessment that analyzes genetic material from stool to profile the microbial community and estimate the relative potential to produce hexa-acylated lipopolysaccharides, the lipid A forms known to robustly activate the TLR4 receptor. Modern sequencing such as 16S rRNA or shotgun metagenomics identifies which organisms and pathways are present, then bioinformatic models summarize the balance of proinflammatory hexa-acylated LPS compared with hypo-acylated variants. Some laboratories complement this with host-response markers that reflect exposure to gut-derived endotoxin. Results capture your current ecosystem state rather than a permanent trait, and they can vary with recent diet, medications, illness, or travel.
Why Is It Important to Test Your Gut Microbiome?
Your gut microbes make molecules that talk to your immune system all day long. Lipopolysaccharides are one of the loudest voices in that conversation. When the community tilts toward hexa-acylated LPS producers, even routine events like a high-fat restaurant meal can generate a transient bump in circulating endotoxin signals. For some people, that looks like a heavy, sleepy feeling after lunch, skin redness later in the day, or a next-morning dip in workout pop. Testing helps identify dysbiosis patterns that elevate TLR4 signaling and may be linked with digestive discomfort, metabolic strain, or immune reactivity. It can also clarify the after-effects of antibiotics, restrictive dieting, or chronic stress on your gut’s inflammatory set point. The test is especially informative when symptoms persist despite basic nutrition and sleep hygiene, or after big lifestyle changes when you want to see how your microbiome adapted.
What Insights Will I Get From a Gut Microbiome Test?
Your report typically presents an index or proportion that reflects the predicted share of hexa-acylated LPS capacity within your microbial community, compared with a reference population. Many summaries also highlight the organisms and pathways that pull the index up or down. In general, a balanced microbiome shows higher diversity with a healthy presence of organisms associated with short-chain fatty acid production and a comparatively lower hexa-LPS signal. Conversely, a community enriched in certain Enterobacteriaceae tends to raise the index. Remember that “normal” varies by geography, age, and diet. Two people can eat very differently and still land in a resilient range if their ecosystems are stable and diverse.
When results lean toward balanced or optimal, it suggests efficient fermentation of fibers into short-chain fatty acids that nourish the gut lining, lower inflammatory signaling, and reinforce tight junctions. That physiology often pairs with steadier energy after meals and fewer swings in appetite or mood. When results suggest an imbalanced or dysbiotic state, you might see reduced diversity, a relative loss of beneficial genera, and a higher hexa-LPS index that points to stronger TLR4 activation. That is not a diagnosis. It is a map of functional tendencies that may underlie symptoms such as bloating, irregularity, or skin reactivity, and that may respond as your diet quality, stress load, sleep regularity, and medication landscape change.




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