Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability—all in one place.

Key benefits of Castelli Risk Index I Test

'- Spot your balance of “good” (HDL) and “bad” (total) cholesterol for heart health.- Flag early risk for heart attack or stroke before symptoms appear.- Guide your doctor in choosing the best cholesterol-lowering strategies for you.- Clarify if your cholesterol pattern needs more attention than just total cholesterol alone.- Track how well your lifestyle or medications are improving your heart risk over time.- Explain if your cholesterol profile may affect fertility or pregnancy outcomes.- Protect your long-term heart and blood vessel health with targeted prevention steps.- Best interpreted with other cholesterol tests and your personal risk factors.

What is Castelli Risk Index I Test

Castelli Risk Index I is a calculated marker that comes from measuring two types of cholesterol in your blood: total cholesterol and high-density lipoprotein cholesterol (HDL cholesterol). Total cholesterol includes all the cholesterol carried by different particles in your bloodstream, while HDL cholesterol is often called the “good” cholesterol because it helps remove excess cholesterol from your arteries. The Castelli Risk Index I is simply the ratio of total cholesterol to HDL cholesterol.

This ratio gives a snapshot of the balance between cholesterol that can build up in your arteries and the cholesterol that helps clear it away. A higher ratio means there is more total cholesterol compared to the protective HDL cholesterol, which can signal a greater tendency for cholesterol to accumulate in blood vessels. In essence, Castelli Risk Index I reflects the interplay between cholesterol that may contribute to artery-clogging (atherogenic) and cholesterol that helps protect against it (anti-atherogenic). This makes it a useful indicator of the overall risk environment for heart and blood vessel health.

Why is Castelli Risk Index I Test

The Castelli Risk Index I is a powerful marker that helps reveal your body’s balance between “bad” and “good” cholesterol, offering a window into your risk for heart and blood vessel disease. By dividing total cholesterol by HDL cholesterol, this ratio reflects how efficiently your body clears cholesterol from the bloodstream and protects arteries from damage. It’s a whole-body signal of how well your cardiovascular system is managing the daily wear and tear of life.

When the Castelli Risk Index I sits at the lower end of the reference range, it suggests a healthy proportion of protective HDL relative to total cholesterol. This balance supports smooth blood flow, reduces inflammation in vessel walls, and lowers the chance of cholesterol buildup. People with lower ratios often experience fewer symptoms and enjoy better heart and brain health over time. In women, especially before menopause, naturally higher HDL can help keep this index lower, offering some protection against early heart disease.

On the other hand, a higher Castelli Risk Index I points to a greater share of cholesterol that can harm arteries, often due to low HDL or high total cholesterol. This imbalance can quietly promote plaque formation, stiffen arteries, and increase the risk of heart attacks or strokes. Men, older adults, and people with metabolic conditions are more likely to see higher values, sometimes before any symptoms appear.

Ultimately, the Castelli Risk Index I connects cholesterol metabolism to the health of your heart, brain, and blood vessels. It’s a key piece of the puzzle in understanding long-term cardiovascular risk, working alongside blood pressure, blood sugar, and inflammation markers to shape your overall health outlook.

What insights will I get from Castelli Risk Index I Test

Castelli Risk Index I is the ratio of total cholesterol to HDL cholesterol. It summarizes how much cholesterol is being carried in potentially artery-clogging forms versus how much is being carried in the “recycling and cleanup” pathway. Because it captures the balance of atherogenic to protective lipoproteins, it links directly to cardiovascular risk, blood vessel health in the brain and kidneys, and, indirectly, to energy delivery to tissues.

Low values usually reflect a favorable pattern of relatively low total cholesterol or relatively high HDL. Physiologically, this suggests fewer cholesterol-rich particles available to enter artery walls and more capacity for reverse cholesterol transport. In most adults, this is associated with a lower long-term risk of coronary artery disease, though extremely low total cholesterol can, in some cases, track with chronic illness or undernutrition.

Being in range suggests that the interplay between cholesterol export and cleanup is reasonably balanced for vascular health. Large cohort studies indicate that risk is generally lowest when this ratio sits toward the lower end of the “normal” span, with slightly different cutoffs sometimes used for men and women due to typical HDL differences.

High values usually reflect higher total cholesterol, lower HDL, or both. This indicates a circulation dominated by more atherogenic particles relative to protective ones, making it easier for cholesterol to accumulate in artery walls over time. At a systems level, this raises risk for coronary, cerebrovascular, and peripheral arterial disease, which can secondarily impact exercise capacity, cognition, and organ perfusion.

Notes: Interpretation is influenced by age, sex, menopause status, genetic lipid disorders, acute illness, and medications that alter lipids. Ratios should be interpreted alongside absolute lipid values and other risk markers.

Castelli Risk Index I Test and your health

Castelli Risk Index I compares total cholesterol to “good” HDL cholesterol, giving a snapshot of how friendly or hostile your blood lipids are to your arteries and long‑term organ health.

Heart & Circulation

- Higher ratios (more total cholesterol relative to HDL) signal more atherogenic particles, raising risk for coronary artery disease, heart attack, and stroke. - Lower ratios generally reflect a more protective lipid pattern and better arterial flexibility. Common drivers: insulin resistance, metabolic syndrome, hypothyroidism, and genetic lipid disorders.

Energy & Muscles

- Worsening ratios often track with poor cardiorespiratory fitness and reduced exercise tolerance over time. - Conditions that improve HDL (regular activity, better glycemic control, resolving liver congestion) usually improve stamina.

Brain & Mood

- Unfavorable ratios are linked to small‑vessel disease and vascular dementia risk. - Extremely low cholesterol (rare) can affect hormone and neurotransmitter balance, sometimes relating to mood changes.

Metabolism & Hormones

- A high Castelli I often travels with abdominal fat, prediabetes, and low‑grade inflammation. - Thyroid dysfunction, liver disease, and androgen or estrogen shifts can all distort this ratio.

Tracking Castelli Risk Index I helps catch vascular and metabolic strain early—before symptoms appear—supporting prevention-focused, whole‑body care.