Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Lead (Pb) testing
- Lead exposure tracking
- old paint, water pipe, and soil contamination assessment
- neurotoxic metal monitoring
What is Lead (Pb)?
Lead is a well-studied neurotoxic heavy metal with no safe level of exposure. It accumulates primarily in bone. Urinary lead post-chelation reflects both recent exposure and mobilized stored lead. Primary exposure sources include old lead-based paint, lead pipes, some imported products, and contaminated soil. Measured via ICP-MS.
Why is Lead (Pb) important?
Lead is classified as a known human carcinogen (per IARC) and neurotoxin, with documented effects on cognitive function, blood pressure, and kidney health. The CDC recognizes no safe blood lead level, particularly for children (per CDC Blood Lead Reference Value guidance). In adults, cumulative lead burden from past exposures can be mobilized over time. Identifying and addressing ongoing exposure sources is a priority.
What insights will I get?
Your urinary lead level may reflect recent dietary or environmental lead exposure as well as mobilized stored lead. Elevated levels may prompt investigation of lead pipes in older homes, lead paint hazards, certain imported ceramics or spices, and occupational exposures.
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