Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Nickel (Ni) testing
- Nickel dietary and industrial exposure tracking
- allergic sensitization and occupational metal monitoring
What is Nickel (Ni)?
Nickel is a common metal found in stainless steel, jewelry, coins, and many foods including nuts, whole grains, and legumes. Dietary intake is the primary non-occupational source for most individuals. Urinary nickel reflects recent systemic exposure. Measured via ICP-MS.
Why is Nickel (Ni) important?
Nickel is one of the most common causes of contact allergic dermatitis. Systemic nickel exposure may contribute to sensitivity reactions in nickel-allergic individuals. Occupational exposures (nickel refinery workers) have been associated with increased cancer risk at high doses.
What insights will I get?
Your urinary nickel level may reflect dietary nickel from whole grains, nuts, and legumes, as well as jewelry, stainless steel cookware, and occupational contact. Elevated levels may be relevant for individuals with nickel allergy or high occupational nickel exposure.
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